The first place to start is with your budget. Determine exactly what you can afford montly. This number has to include your mortgage, mortgage insurance if necessary, homeowners insurance and property taxes.
Next you need to pre-qualify for a loan. Research lenders rates & fees and with their help determine how much you can qualify for.
Then find a realtor you like and start looking at houses. The realtor can inform you of any additional fees or expenses you may incur.
Then protect your investment by having it inspected by a professional home inspector. They will inform you of the condition of the home and let you know about any problems there may be. Afterwards, if that house is for you - buy it. If not - keep looking until you find the home that's right for you.