I am glad to hear that you are relocating to the St. Louis Area. St. Louis City has many distinct and fantastic neighborhoods and the Tower Grove area is certainly one of them. If you are concerned about crime statistics you can gather that information from the St. Louis Police Departments Website.
Just to give you a little background on the Tower Grove Area: this is one of the most popular up and coming areas in the city. Over the past few years there has been a ton of rehabbing and renovation in the area, and it is now a hot spot for young people and families who are looking for a great home in the city. There are many new businesses, shops, and restaurants who cater to this neighborhood. However, you should keep in mind there are still some areas in transition. My best advice is to work with an agent who is knowledgeable about the CITY (You will find there is a difference between the City and County in St. Louis), tell the agent about your needs and what you are looking for in your new home. Things like price, type of home (single family, multi family, loft), neighborhood amenities, proximity to work locations, and schools are all things that a good Realtor should ask about. Once we have this information we can steer you in the right direction and ultimately help you find the home that is perfect for you.
As a Realtor who works extensively in the city, I would be more than happy to answer any further questions you may have. Please don't hesitate to contact me.