It would be best if you could make money or at least break even. But it depends on your situation. Such as if you must move to a new location, and you are unable to lease it out, and cannot afford to make the house payment and pay rent or buy a new house where you are newly located, then it might be better to take a small loss just to get out of the monthly payments. If you start missing your mortgage payments, it will be hard to catch up, and then after missing so many, they may foreclose on your house, and then that would hurt your credit for a long time. You may not be able to get a loan to purchase another house in the future. Good luck in what ever you do.