Well, first, do you have a problem?
Being upside down on a house isn't itself a problem. If you are able to make your payments, you make your payments. After a while, as the real estate market improves and you pay down your mortgage, you won't be upside down any more.
So, just owing more than your home is worth isn't enough for any "program."
If you're not able to make your payments, then you have a variety of options. You can ask your lender for a loan modification. The lender, naturally, will want to make sure that you need a modification. Often, though, that's a reduction in the interest rate, not a reduction of the principal.
If you can't make your payments and your lender won't grant a loan modification, you can try for a short sale. Again, though, you'll have to justify hardship. And, again, your lender will have to approve the sale.
If you go that route, there are a couple of government programs--HAMP and HAFA--that are supposed to speed up the process.
Hope that helps.