TEX, Here is the affect on your cost of living:
Salary in Tyler TX: $100,000
Comparable salary in Columbus OH: $109,882.66
If you move from Tyler TX to Columbus OH...
Groceries will cost: 7.79% more
Housing will cost: 22.033% more
Utilities will cost: 11.159% more
Transportation will cost: 11.05% more
Healthcare will cost: 7.569% more
From CNN MONEY (C)
I believe you can make it up on investment property, though, if you like that hedge.
What areas to avoid depend on personal preference and criteria.