If you are having difficulty paying your mortgage payment, and can demonstrate a hardship to your lender, there's a chance they will work with you. It's not a guarantee, but there's a chance. You'll need to contact your lender and see if there's something they might agree to do for you. If you are fully paid up (no late payments), they probably won't believe you are in a hardship. Missing payments will kill your credit, but it may get their attention. Or, it could fail, and you end up with bad credit, and nothing to show for it.
If you can pay your mortgage just fine, and are unhappy that your investment has lost value...well, that's a different story. Nearly every home owner in the US is unhappy their home has lost value.