It depends, of course, because for all the hard data that today's buyers examine, the home still has to have a coherent "feel" about it.
My first thought is that floor-plan modifications generally harm resale value, and, "sight-unseen," it seems to me that you're going to have two "bonus" rooms, one with a man-door, and that's just going to seem strange, rather than beneficial.
I'd have my agent come by with my contractor and designer/architect, and ask my agent's opinion. In actuality, this could turn out to be a good idea. But I can't imagine it.