Yes there are definitely homes with guest homes available. Some could be as small as a 2 bed 1 bath home with a detached studio apartment in Plaza-Midwood, all the way up to the homes on Bonds Grove Church Rd where one home is about 30,000sf with 2 guest homes - a 3,000sf and a 4,000sf home.
The issue you may have with finding what you're looking for is because there is no specific field in our MLS system that allows you to search by guest home. At the least, an agent would have to do a keyword search through the remarks section. But even then, that's assuming the listing agent mentions it in the limited remarks section.
A good agent should know how to look this type of property up through the public tax records and then cross-reference with the active listings. An even better one would know how to contact the ones that aren't listed for sale to see if they would sell.
I'd love to help you out in any way I can. Call, text or email me anytime.
Eric Cox, Principal