I live in that neighborhood. When we bought, I was concerned about the train, but the homes have some really nice features, and the location in proximity to the park, shopping, freeway, and, ironically, the train station to get downtown, couldn't be beat.
We also bought at a good time, so we were never in a situation where we couldn't move if the noise were an issue. We've owned and rented several homes and apartments, in several cities and states, as we've moved for work, and the train is one of the best neighbors that I've had.
We've been in our home for over 8 years, and the train has never been a problem. Most trains are metro link, which are light passenger. From a sound perspective, that means that they are not loud or long. I rarely notice them. A few times a week, a large freight train comes through, and if we are outside, we will hear it. Does it impact our BBQ? No.
Are the whistles a problem? No. Crossing bells? No.
How often do I have to wait for a train at the crossing? Maybe once a month I'll hit the crossing at the same time an Amtrak or Metrolink hits the station. The crossing is down for maybe a minute - less than a stoplight. While the train is in the station, the guard goes up.
What about an emergency? What if there is a fire and the train is blocking the way out? We have several alternative exits that would be opened in that event that would allow for both the emergency vehicles to come in and for residents to get out.
To summarize, if you absolutely hate trains, avoid Simi Valley, Moorpark, large swaths of the valley, Camarillo, Ventura, etc. If you're concerned about the noise at a specific house in this neighborhood, ask the neighbors, arrange to be there when the trains are running, and see for yourself.
There is something nice about tossing a change of clothes in a suitcase and walking down to the station to catch a train up the coast. It's pretty cool to walk down and grab a train for a summer trip with the kids to Olvera Street. It's super easy to get to the Dolby Theater with out of town friends. Show at the El Capitan?
I looked at the home that you called out, and with the front yard facing the direction of the tracks, several homes between that home and the tracks, and the train being a distance away, I doubt that you would even notice the train.