"Safe area" is a relative term. Try spending some time there during different hours to get a better feel for the neighborhood.
Oggi Kashi - 415.690.3792 direct
Broker Associate, Paragon Real Estate Group CA DRE 01844627
All data from sources deemed reliable but subject to errors and omissions, and not warranted.
I agree with Oggi Kashi. A "safe area" is relative. I also recommend spending time in the neighborhood to see if it's a good fit.
O'Farrell on the north
Mason on the east
McAllister to the south
Polk to the west
California Street is a long way from the tenderloin. It's actually Nob Hill and you see plenty of people out walking to the bars and restaurants in the area. Although you always want to be careful in any city, this is not an area I would be worried about.
That said, it starts getting sketchy fairly quickly as you head south.