I would say that the Tower District is one of the most distinct neighborhoods in Fresno. It's known for its night life and eclectic culture. You can read more here: http://www.towerdistrict.org/ . The Tower is also one of the most walkable parts of town.
I would say you've got three choices:
Naturally the area around the College, especially around the Hot Dog place at Shaw & 168.
Second would be the Tower District; I understand a lot of youngins want to live there.
Third would be around Riverpark; lots of Appartments and Condos.