Hi, Big Nugget.
I don't put much stock in the average price per square foot of one neighborhood to another. WIthin any neighborhood, you will see a very huge range. You are comparing the Upper East Side, a very big neighborhood, with Tribeca, a small neighborhood. Within the Upper East side, the prices are higher near Lexington Ave. and go down as you go east. Other factors are whether you are comparing co-ops to co-ops and condos to condos, or comparing condos to co-ops which you can't do. Different product. Furthermore, much depends upon the type of building, the amenities of the building, the condition of the apt, the floor it is on, the views, etc. Neighborhood averages are not useful when comparing one property to another, which may vary greatly.
Halstead Property, LLC