That varies depending upon the restrictions of the neighborhood and style of house. For example, there are some neighborhoods where the architectural covenants require a large amount of natural products be used for the cladding of the exterior of the home. As for house style, the least expensive style to build is a saltbox--a home where both the 1st and 2nd stories are stacked right on top of each other. Where the saving exists in this style is that the foundation and roof system end up covering 2 floors vs. a single story or ranch style home where there is more foundation and roofing for a single story.
That being said, currently you could plan on a 2 story running between $110-$130 per sq. ft. and a ranch style upwards of $150/sq.
Again there are a lot of variable but this should give you a starting spot.