As the others before me have said, it really depends on how you intend to use the property. If you are going to live in the property and run a business out of it, then commercial zoning will give you the best visibility.
On the flip side, your buyer pool will be limited when and if you sell.
If you do decide to go this route, do your research (or have a buyer agent do it for you). Make sure you buy in an area that has held its market value throughout the years and will give you a good return on your investment.
Best of luck! Please don't hesitate to contact me directly if I can be of any assistance.
RE/MAX Signature Properties