It is always subjective regarding one's impressions of a neighborhood. My office is in SoHo, and as a SoHo expert, you won't hear a bad thing about it from me. I can tell you that it is just about the priciest neighborhood in NYC. That tells you somthing. I would suggest you spend some time there. Obseve the unique cast-iron architecture, the variety of shops, restaurants and services, the proximity to subways, and all the things that are important to you.
Hope this helps.
Halstead Property, LLC