The reality is that "getting on the MLS" will only be beneficial to you, if you are offering some form of compensation to a buyer's agent to ultimately bring you a performing buyer. The MLS is used exclusively by real estate agents, and if you aren't willing to pay them - they simply won't show your property to anyone.
Your question didn't specifiy whether you simply want to sell your home yourself, or if you want to save 100% of the commission. You can certainly save the listing side of the commission, but if you aren't willing to pay anyone who procures a buyer for you - you are eliminating a huge portion of qualified buyers who are working with real estate agents.
Selling your home FSBO can certainly be done with good results. It comes down to how much you value your time and energy. If you don't work, have nothing but time on your hands, and want to devote most of that time to marketing your home, coordinating the showings, and spending money up front to advertise - then I would say definitely go for it.
There will always be a certain percentage of people who want nothing more than to rid the world of real estate agents, lawyers, accountants, etc. etc. etc. These people envision a world where you do everything yourself, and never pay anyone for any type of service. The reality is however, that as long as there are people who don't have the time or desire to sell their own house, do their own taxes, and draft a will or represent themselves in court - there will always be a business need for these service industries.
At the end of the day it boils down to - do you want to try it yourself, save the money, and "maybe" do it right, or do you want to pay to ensure it is done right. The difference with a FSBO is you pay either way, however with a FSBO you pay upfront without guaranteed results.