Before moving to WA I was 15 years in Sacramento. I've helped seasonal workers on the central valley farms, piecemeal workers, etc. Whether you can qualify for a loan immediately after gaining employment again will depend upon whether unemployment is a regular occurrence in your industry, how long you've been out of work, etc.
Some very general statements - if you've been out of work for only two months out of the last two years, obtain employment in the same line of work, etc. you are probably ok.
If you were a salaried employee before and gain employment that pays you by the hour and the hours are not guaranteed at 40 hours a week...you might have a problem.
Under no circumstance that I can think of will you be able to obtain a loan approval without employment.....unless it's an FHA loan and you have a direct relative that can qualify to co-sign with you.
if you have specific questions or want some additional help, just let us know.
As for unemployment if you won't be out of work longer than 2 or 3 months and you get a job in the same line of work and it's explanable as to why you were out of work usually a bank will accept this.
please remember all other things must be inline as well. Credit, income to debt ratio, and money to purchase.
All the Best
Dave & Lisa