I am also trying to answer this question for myself!
The houses in the north seem to be on slightly larger, wooded lots and seem more remote/isolated/private & quiet. It's also on a bit of a hill. Less sidewalks, more nature. I would just be wary of any lots too close to the highway (422) so you avoid the dust & pollution of high speed traffic.
The houses near the school tend to be on smaller lots but seem more neighborly (smaller lots, more densely packed houses) with sidewalks, streetlights, and places to walk. If you are near the schools you will be much closer to the community center, library and park.
Most of the business areas are concentrated in the middle between the north/south.
Solon has two streets that run parallel (SOM Center and Cochran). On Cochran there are many businesses, some factories (the Nestle factory, for one) and there is a lot of traffic in/out during rush hour and at lunch time. It is probably easier to navigate and get on the highway at rush hour if you live north of town.
I might avoid the southern most part of Solon (along Pettibone) as sometimes there is an odd smell around here, especially in the summer.