After growing up and working in Framingham, I'm a firm believer that the school system is great, providing a diverse community for your children to learn in should you have any! A location south of Rt. 9 will be closer to Loring Arena, the local hockey rink, as well as the Little League Complex. There is also more water on this side of the town in terms of ponds and lakes/reservoirs.
The section of town north of Rt. 9 will provide closer access to amenities such as the high school and may provide easier access to the Natick Collection and other shopping amenities. Both sides of Rt. 9 offer various dining options, but most rest along the Rt. 9 corridor, excluding Gianni's Pizza (north of Rt. 9), one of the best slices of pizza I've ever had, and La Cantina (south of Rt. 9) boasting amazing family dining options. There are libraries on both sides town, and you will find the Metrowest Medical Center and family-owned establishments such as the Framingham Bakery and Tosti's Service Station, south of Rt. 9.
I hope this helps! Please don't hesitate to ask should you have any other questions!