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The best thing you can do is put in your best offer the first time. You may not get a second chance to make a higher offer. It is imperative that you have a good realtor with knowledge of escalation clauses if you decide to go that route. One of the biggest factors in your offer is the knowledge of what kind of sale it is (i. e. regular, short sale, foreclosure). If it is a regular sale or foreclosure, they are usually most concerned about their bottom line. The highest offer. Because the seller in a short sale does not get any money out of the deal, escalation clauses do not play as big of a factor in that kind of transaction. Hope that helps. Wish you well!