That's a toss up. Direct lenders tend to be much faster in getting loans done and homes closed with less red tape.
Whenever dealing with a large corporate entity such as Chase, there are always more layers to get through and harder to get things done. The last time I worked with a Chase loan, it was difficult and we did close late.
Perhaps you shoud interview 2-3 different lenders, compare rates, costs, etc and then make your down decision. I would also ask your Realtor who who he or she recommends.