That's pretty general and Colorado is a big area. Can you elaborate on your situation? Do you want to be within a certain distance of a metropolitan area (ie, Denver, boulder, Colorado Springs) for jobs, healthcare, schools, shopping, etc?
Would this be your primary residence or a vacation home?
What price range?
What do you mean by "many acres"? 5? 20? 100?
What size home would you like (# of BR/BA, square footage, garage spaces, etc)
I've lived in Colorado my entire life and know the state pretty well. I've lived on Colorado's "front range" for 20+ years in Boulder County.