Highway noise is a very subjective issue. Which highway you'll be proximate to will also be a deciding issue as to road volume. If you're working with a buyers agent then you can look into historical neighborhood data over the last several years to see how that has affected values. Depending upon how long you are planning on living there you can also look into natural sound barriers if given enough time to grow. Landscapers can give you additional ideas on sound breaks. Alot will depend upon the properties proximity to the roadway involved. To some and I use as an example people from Revere, Winthrop or East Boston it might be quiet compared to the aircraft from Logan, others it may be unacceptable. You could also take decible measurements prior to offering and seeing what those numbers mean. Many sections adjacent to major highways have been slated for sound barrier coverage, this might be something to look into on the local & state level to see what progress has been made. For example all along the Rts. 93/128/3 corridors people have for decades advocated for better barriers to be met with some success from the state & federal govt. You could look into this.
At the end of the day does it satisfy your needs & is the home insulated from the noise or will you have to retrofit? Is it acceptable for you? I would suggest visitng the property during several days at rush hours to see what actual noise is while you're there. It's a bit more work but the legwork pays off.
I once sold a home located adjacent to a train tracks, I made sure that the prospective buyers were there when the trains went by so they could verify for themself what is acceptable with them. There's no hiding it at the end of the day, it will all depend upon the eyes of the prospective buyer & the market conditions at the time you sell. Which properties you are up against, pricing, features etc.
Good Luck, check back & let us all know how you made out & what decisions you made & what influenced you,