Assuming that you meant you paid more for the home that it is worth, rather than less, the short answer is yes. A creditor can always sue a debtor for payment of a delinquent debt regardless of the reason that you failed to fulfull your agreed obligation to pay under the terms of the lending agreement.
The exception is when the debtor has filed for bankrupcty protection. But if you are not financially distressed,and not eligible for bankrupcty protection, or you just wish you had made a better deal, the law does not afford protection on the grounds of buyer's remorse.
If that were so, can you imagine what it would cost to borrow money?