Ouch. It is not going to be pretty, but you already knew that. I used ot have a friend that lived in Aguroa who commuted to Glendale for work. It was about an hour, give or take depending on how the 101 was behaving that day.
Why don't you move to Pasadena? We have great neighborhoods, shopping, cultural activities, restaurants, and are in close proximity to all downtown LA and Hollywood have to offer too.