If you are a home owner, not a renter, parking is easier because you can get permit parking - which means you can park in your zone and you don't have to worry about the time limit posted. For being so close to Center City, parking in the Art Museum area isn't bad. 1500 Mt. Vernon is close to CCP, so you might have to fight with some college kids for parking, but I think most of them take public trans.
TONS of development in that area. Prices have certainly gone up in all of 19130 zip. Lots of condo conversions and new construction.
Terms like "safe" really are difficult for me to comment on... Are you a city dweller? Sometimes people who haven't lived in the City have different expectations of safety than those that have lived in the City. It really depends on your comfort level. Can you park a BMW there, yes. Should you leave your wallet on the seat, no. Can you walk outside at 2am, yes. Should you be wearing lots of jewelry, probably not... But really that rule applies to every part of the City.
If you are looking to buy on that block, if you are smart about what you are buying, you'll enjoy the neighborhood.
Let me know if I can help at all. I'm always happy to talk real estate!!! No obligations.