Safe... the only thing you'll have to worry about is how much you'll have to spend on a martini after work or a possible steam explosion. There are few if any neighborhoods in Manhattan these days that are still shady after dark and Murray Hill will not be one of them.
There are a few great resources around. I think it is best to contact your Community Resource Officer or CRO at the police department. Just call the main non-emergency number and ask to be connected to the CRO. Theyâ€™re normally very aware of the good and bad areas of the area and can normally give you local statistics. You can also check out http://www.ojp.usdoj.gov/bjs/ which provides stats based on the FBI uniform crime reports. You might also visit the FBI stats site at http://www.fbi.gov/ucr/ucr.htm#cius. Another place to checkout is http://www.Crimeweb.net . Hope this is of you to you.
Sofia, that's where Lucy and Ricky lived, no? You brought back memories. I left NYC 6 years ago but you may want to contact Mitchell Hall. He's a Manhattan realtor who may be able to provide you with guidance. His profile is listed here at Trulia.