I must agree with Ann below. This is a question that should not be answered by a real estate agent, but rather by a financial consultant who is familiar with your specific financial picture. Real estate agents are forbidden, by LAW, to give you financial or legal advice. The reason for this is that every person's financial picture is different and there may be factors related to your personal life, business, or other considerations that factor into the discussion. The question can only be answered taking into account your total situation....anything else is simply speculation.
And some quality of life issues, also personal, simply can't be easily quantified. I would personally love to live somewhere where real estate costs less, but hey, the bay area keeps pulling me back. The weather is gentle, you have access to the entire world right here, the job market is way above average, so there's lots of opportunity.
Good luck to you.