When priced right, everything sells and everything rents with no problem.
If it is a "red zone", the common sense should tell you, that you may not be very successful with a short term/ vacation rental, but will have to look for a long term tenant.
I hope there are realtors in your Florida family to help you check the background and the credit worthiness of your prospective tenant.
Good luck with your investment.
PRAG Realtors, Inc