It's your wish, you can do it like you want. As for me I would like to have access from the guest room, because when you invite your guests it is important to get to bathroom fast. I also have two bathroom in my house, so anybody always can get there when he wants. Actually you can find good company who will help you with your remodeling. They are professionals and they make nice and comfortable project for you. For example I worked with this company https://aaaconstructionandsolar.com/home-remodeling/ Recomend them!