Credit score is but one factor used in underwriting approval. it is the first hurdle, but also taken into consideration is job history/stability, salary or variable contract work. Also look at total debt to income ratio and liquid assets. I have seen people with decent credit scores denied loans because of too much overall debt or job instability. Owning your own business can be tough too because they look at net income not gross income before expenses. Rule of thumb is 18 months in the same job. Plus they want to get 2 years of most recent taxes.
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Best of luck!