Nick. I'm not sure if you mean from a crime standpoint or how the market is performing vs the Twin Cities area in general. From a safety standpoint, The residental neghborhoods in downtown Minneapolis are quite safe. Trulia provides useful maps showing where the hot spots are for crime - and in downtown Minneapolis that tends to be in the nightclub district. If you were to ask loft owners about this, I'm certain that the vast majority would tell you that they feel safe. You can also get info on this from the Minneapolis Police Department if you'd like more statistics.
If you're talking about the market safety, downtown Minneapolis is currently outperforming the Twin Cities Metro in terms of growth and appreciation. More and more people are discovering how appealing the downtown lifestyle is and everything that downtown has to offer. Most new development is currently rentals, which will be beneficial for condos owners due to supply and demand. This is a good time to be a condo or loft owner in Minneapolis.