As others on the thread have commented, we're not legally allowed to answer questions about safety. You should definitely do your potential commute, especially at night, and see if you feel safe in the neighborhood.
That said, I've lived in South Harlem for a few years and enjoy it very much....especially the convenience compared to similarly-priced areas around the city.
If you'd like to chat or see some places, I'd be happy to help you!
Good luck in your search...