I had worked for a Wall St. Company for years, and from East Brunswick where I live, it was a 50 minute bus ride to downtown Manhattan. The Mid-town trip is have heard is about 70 minutes. It depends on what you are talking about "uptown". Anywhere in this area, is going to be about 90 minutes. Red Bank is probably 2 hour.. plus.
What is your motivation for buying in East Brunswick? if it is the school system, then the commute is worth it.
Email me for me for detailed information about East Brunswick, the schools, commute.. ups and downs.
Also see my listings on Trulia for some of my East Brunswick properties.