Good morning Doug. Whether you are coming from SSF or the South Bay on your way to SF you can go one of three ways. 101 is the shorter route but because of traffic will probably take you longer, or you can take 280. 280 is a much nicer ride, more scenic. Or If you would prefer, you can always take either the train or bart as well.
If you are coming from the South Bay, Bart goes as far as Millbrae.
IF you need any help finding a home, please do not hesitate to ask. My team does a lot of business in SSF and San Bruno.