Go rent the movie "War of the Roses".
If you are not represented by a Realtor, than you can drop a note card in the mail and see if they respond. I am bit curious as to why this particular home interests you. Is it the property, or circumstances surrounding the property? If it is solely the uniqueness of the property, incorporate those thoughts in your note, explaining why their property may be right for you while others on the market are not.
If your interest in the property is predicated upon circumstances that you believe may cause the owner to want to sell, the property owner may be guarded about your motives. i.e. Did you hear they were being transferred? Is there a pending divorce? Are there financial pressures which could cause them to sell?
If any of the above are factors, your note may cause the owner to be cautious.
Sometimes Realtors have better success than individuals in an outreach to an owner. You might also consider finding an agent to represent you and aksing them to make the approach.