Good luck! I help a lot of people relocate here, just last week closed on a couple moving from Pitsburgh!
You don't mention where you might be moving from. I think knowing that information would help give a basis to compare the quality of life in Greenville. Greenville is a really neat place to live in SC. It doesn't compare in size to places like Atlanta, Charlotte, NY, LA, etc when it comes to shopping, dining, etc. Greenville is a great supporter of the Arts and has activites indoor and out almost year round. Post where you're moving from and I'll be glad to do a comparison on the communities for you.