I would go 280 to 380 to 101 and then take the cut over (280) to 6th or 3rd (AT&T park) and work my way into the city. You also could take 101 all the way in, but traffic gets pretty heavy once you pass the 280 cut over. You also can take Cal train to 3rd (south of market) but will have to take a bus/taxi to your work.
My friend highly recommends the train. She lives in Palo Alto and gets on at the University station. Takes the express. She loves being able to do work, rest and read on her own while she commutes. She swears by it. Sounds like a great use of time to me.
It'll give you options to go 101, 280, or 101 and 280.