This kind of question could fuel an endless debate among San Franciscans, as it seems the amount of restaurants in SF are unlimited. You can find superb restaurants in just about every neighborhood in San Francisco - a lot of the criteria you use to value and judge a restaurant is really what drives your decision.
If I had to rank, I'd probably say the Mission is probably one of the best neighborhoods for foodies; There's a mix of eclectic eateries as well as top-ranked establishments that always seem to make the "best of" list in almost any guide. SOMA, North Beach, the Marina and Hayes Valley also all have top-ranked places to dine.
great show and lists so good places too