There are pockets of drug use and manufacturing, but it tends to be very localized. Just check out the immediate neighborhood when you plan to buy or rent thoroughly first. Your realtor (ask me for an introduction for one if you need one) should be knowledgeable and able to help with this.
The only real down-side about Otis is that you end up driving everywhere, but it's beautiful all the way! So if you don't mind trekking around in the car with the kids, you'll love it.