Depending on where is Port St Lucie and where is West Palm Beach you are going, but anywhere from 45 minutes to an hour (and depending on traffic/time of day you're driving). I see you are looking at a home in Tradition which is right off of I-95 so that will help with your commute. My husband works down in Palm Beach Gardens and it takes him approx. 45 minutes to get to work and we live off Bayshore. Hope this helps.