I can tell you from experience the area has picked up in foot traffic. You have Eataly on 23/24th that is a major contributor. Many new developments in area and also in construction (toy building, 225 fifth, all of 26th b/w 5th and Mad-and new hi-rises on 6th around 23rd and north). I presume you are looking at retail.
Demographic can be found below, refer to map section 58/56
Here some more info on residential buildings +...