The location DOES make a difference - Metro areas will be more. Expensive towns will be more ... etc. etc.
A typical 5x8 bathroom with tiles on floors walls, mid-range, would cost about $12000 without demolition.
Here is a tool for you to estimate new bathroom remodel
The previous answers are all correct it just depends on the detail and how fancy you would like it to look. I've seen some more simple bathroom remodels cost $3,000 to some more extreme remodels costing over $20,000. Being a realtor I would advice you need to consider if your bathrooms are bringing the appeal of your property down from a resell value stand point. I would create a couple of budgets Ex: under $3,000, under $5,000, etc. Then have a qualified contractor give you some estimates of ideas of what kind of remodel they can do in those price ranges. Also always get more than one estimate on work.
It does vary somewhat depending on location. But more of the variation depends on how basic or how fancy you want the remodel to be.
If you're considering it, first get a good idea of what you want. Then get bids from at least 3 contractors. You'll be surprised at the price variation. (And the most expensive one isn't always the best or the one you should go with.)
Hope that helps.
Yes, the cost of labor will vary from one location to another. Contractors in areas with higher cost of living will demand higher prices than those in areas of more moderate priced living expenses. For instance, labor costs are higher in San Francisco than in Kansas City. You may be able to find a contractor who needs work now to do the work for a lower price than a contractor who has jobs lined up for the next 6 weeks. Check around. It's a good idea to see work the contractor has completed before hiring him/her to work on your project. At least get some references first.
Exquisite craftsmanship with high end materials will cost more than poor craftsmanship with cheap materials. Most people are comfortable somewhere in the middle.