When you have narrowed down an area based on your needs and price range, look at the demographics. Once you have it narrowed down I would suggest spending a Saturday doing the things you would normally do. Gym, church, shopping, walking around downtown.... You will get a "feel" for what works for you.
Out of the many great Denver neighborhood I am partial to the North East Denver neighborhood of Park Hill. We moved here from Oklahoma in the '60s and settled in Park Hill. There is something for everyone. There are a few homes still actually under $100,000 remaining and upto over $1,000,000.
The best featurea are the big trees, great archetecture, quiet streets and more. We are nestled between City Park and the new Stapleton development center. and from Colfax to I-70. With the old world charm and the convenience of Stapleton it is the best of both worlds. Everything from Denver Squares, Victorian, and Tudors, to the solid brick post war '50s ranch homes make it a quaint and comfortable place to live. My Mother still lives in the same home we moved into in 1964. some of our neighbors have been there that long as well. Also we have an influx of new residents from all the suburbs that love the convenience and the proximity to Downtown Denver as well as all of the other amenities. Park Hill has been nationally recognized for it's diversity as well as beauty and convenience. Thanks for asking. What is your favorite.
Check out http://www.kennarealestate.com for info on Available homes, foreclosures, and sold home data.