First off, congrats on making the move out further west to America's Finest City. San Diego is an amazing place that appeals to people for a variety of reasons and depending on what your interests are as well as where you will be working, that will dictate where to move. The one downside to being such a desired place to live is the traffic which can build up in certain areas and you will want to be cognizant of this (I always recommend doing the commute before purchasing so there are no surprises.) Many people come for the endless miles of coastline and if you are looking to live on the coast, you will generally pay a premium for that and often times, it is 10 degrees or so cooler and overcast, as opposed to living inland. There are far too many neighborhoods and areas of San Diego to go into detail here, but I'd be more than happy to discuss what would work best for you depending on your needs.
Here are some of my favorite neighborhoods in San Diego.
Cardiff- Near the beach, hip, younger families, but not the cheapest. A single family home will go for $600K plus.
North Park/Normal Heights- Trendy, urban, craftsman/character homes, close to downtown...homes are definitely older...people tend to want to fix them up. The homes start as low as 200K, but the square footage is quite small at that price. Really cool bars, restuarants etc.
Carmel Valley- Arguably the best schools in the county, near the beach....you can do a condo around 400K, homes can get pricey.
Poway- Great schools and great bang for your buck. Safe community, awesome school district, but you are inland a little ways.
There are a lot of great places in San Diego. Let me know if we can help you out!
San Diego is great and has many great areas. As others stated you needs and buget will determine what areas. You are better to give more specifics on what is important to you, what your needs are and what your buget is and then some areas can be given for consideration.
That is a tough question to answer. I don't have enough information about you, your needs and most important, yes the all important budget. You will find that San Diego prices are much higher than Arizona and that though the housing market has taken a beating, here in San diego it is not that obvious.
Good luck with the move.
Keller Williams Realty