You will need to get the property rezoned with the city. Contact the Planning and Zoning Commissioner and they'll walk you through the process. With commercial all around you, it sounds like you can make a strong case for being able to rezone your home to commercial and list it as a commercial sale. It also sounds like a much better resale opportunity to sell it as a business rather than as a residence.
You might get some interest in the property as a commercial lease. Don't instantly shy away from that as an option, as it could be quite lucrative even in the short term. If you can get a business to move onto the property, you might possibly achieve a higher return if you sell the property with a commercial tenant in place.