Buying a house in Wynwood or around will be great, because the values in the area will be rising in the future, and so it will be a good investment. I agree with the separate "good lighting" studio being a good option. Or, maybe a 2 story condominium with the loft...
Buying a house would be easiest in terms of getting financing (comparing to a condo or a commercial purchase). However, beware of code violations (we have a lot of those in Miami Dade county).
Hope this helps,
Beachfront Realty, Inc.
Since my mother is an artist near Wynwood, I would be more than happier to help find you the ideal space.
Feel free to contact me with specifications such as what you are looking to accomplish.