I would agree with the vote for Northeast Chatham County. I live there myself and my wife easily commutes to RTP, while I work out of an office in Chapel Hill. We are 20 minutes to either shopping areas in Apex or Southpoint and about 30 minutes to the airport. Even getting to downtown Raleigh only takes us about 30 minutes. Soon 540 (our outer belt line) will connect to Hwy 64, making it even easier and quicker to get to Cary, RTP and the airport. Having relocated here from Boston myself, I work with a lot of people coming from the Northeast and the common connections and background can be a big help. I grew up in SW Connecticut and spent a lot of time in NY as well. For some more information on the area, check out my relocation Smart Magazine through the web link or feel free to get in touch if I can be of help or send you some sample listings.