I would recommend going to the crime rate website for the counties/cities you are interested in moving to. That alone should be able to give you an idea what locations would be preferable to the two of you. It is unethical for an agent to provide that advice for you as perceptions vary person to person. Lastly, what has your Realtor told you regarding potential re-sale value of the homes you are looking at? If you are interested in buying a home to "flip" within the next couple of years, prices seem right; however, you may want to look at short sales or foreclosures. Although they take longer to "buy", you may be able to find some great values.
What does your agent say? Resale is iffy these days. If I had to prognosticate, I'd say that North Loop has a more broad appeal and will in the future due to the Twins Stadium and other projects that are coming in the future. That's based on my own research that I've done for other clients.
As for crime rates, no agents should be offering you advice about that. City of MPLS has wonderful crime maps for you to look at. That way, you're making a decision based on what you think is acceptable, not what anyone else thinks.
Resale value is a tough question these days. Very few sellers were prepared for the current market adjustment. Percieved crime rates are just that. Perception. The only way to quantify that is to talk to your friends and co-workers. I can't comment on it. Check out the link to MPLS crime rates.
Good luck out there!