I hope that this helps.
Living on the east side of Hwy 101 spectacular and the weather is usually better with less wind and fog. Definitely a better place to be if you're into gardening.
It depends on what you mean by "better" and "East side". As far as the weather goes, it is pretty much the same year round right next to the ocean and directly on the East Side of hwy 101. The weather gets notably better during the summer if you go East up the Alsea, Yaquina or 10 Mile rivers. And by "better" I mean you will miss the "Junuary...(fog and cold weather in early summer)" that people get directly on the ocean and will generally have nicer, warmer summer weather as little as 2 miles up river.
Some people really enjoy storm watching with ocean views as well as forest etc views, as we get very dramatic coastal storms.
Let me know if I can give you more insight to your question, hope this helps some!